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KMID : 0356820080240020169
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Korean Journal of Head & Neck Oncology
2008 Volume.24 No. 2 p.169 ~ p.173
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Concurrent Chemoradiotherapy in Nasopharyngeal Carcinoma
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Chung Eun-Ji
Kim Yong-Tai
Hong Hyun-Jun
Hong Won-Pyo
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Abstract
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Purpose: This is a retrospective study to evaluate the results of concurrent chemoradiotherapy in nasopharyngeal carcinoma.
Material and Methods: From Mar 2000 to June 2005, 18 patients with nasopharyngeal carcinoma completed planned concurrent chemoradiotherapy. Stages were I in 1 patients, II in 2 patients, III in 7 patients and IV in 8 patients. Pathologic type was squamous cell carcinoma(WHO type 1) in 2 patients, non-keratinizing type(WHO type 2) in 8 patients and undifferetiated carcinoma(WHO type 3) in 8 patients. The follow up period ranged from 30 months to 95 months with a median of 56 months. Follow up was possible in all patients.
Results: Response to concurrent chemoradiation therapy was a complete response in all patients. Patterns of failure were as follows：local recurrence in only one patient(5.6%) and distant metastases in three patients with N3 diseases(16.7%). The overall 5 year survival rates were 88.5%, the 5 year disease free survival rate was 77% and these were very good results. There were no significant differences in the local control and survival rates between the clinical stages and pathologic types.
Conclusion: The outcome of the nasopharyngeal carcinoma treated with concurrent chemoradiotherapy was very good, even though most of the patients(15/18=83.3%) were in stage III and IV diseases. We concluded that concurrrent chemoradiotherapy in nasopharyngeal carcinoma showed the good local control and survival rates without significant complications. In the patients with N3 disease, we have to consider the more effective and strong chemotherapeutic regimens to prevent distant metastases.
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KEYWORD
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Nasopharyngeal cancer, Concurrent Chemoradiotherapy
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